Judy H. Cho, MD
Director, Charles Bronfman Institute for Personalized Medicine and Ward-Coleman Chair for Translational Genetics, Icahn School of Medicine at Mount Sinai
Director, Charles Bronfman Institute for Personalized Medicine and
Ward-Coleman Chair for Translational Genetics
Icahn School of Medicine at Mount Sinai
Judy H. Cho, M.D., is director of the Charles Bronfman Institute for Personalized Medicine and the Ward-Coleman Chair for Translational Genetics at the Icahn School of Medicine at Mount Sinai. Her research focuses on inflammatory bowel disease (IBD) genetics and disease mechanisms and is applying single cell RNASeq and CITE-Seq to define clinical and pathophysiologic heterogeneity in IBD. Dr. Cho has served as principal investigator of the Data Coordinating Center of the NIDDK IBD Genetics Consortium since 2003. She has led efforts in identifying over 200 IBD associations, notably NOD2 and IL23R. Loss-of-function, protective alleles in IL23R confirmed that targeting this pathway should be effective; neutralizing monoclonal antibodies against IL-23 are now approved for a variety of inflammatory traits. Since 2015, Dr. Cho has managed the School’s blood-based biobank of samples and matched clinical data from over 50,000 patient participants. These efforts have catalyzed genetic discovery and implementation to improve the care of individual patients. Single cell analyses of inflamed tissues in Crohn’s disease have provided a fine-scale, precise window into modules which correlate with anti-TNF response and non-response. Given the substantial pleiotropy across chronic inflammatory diseases, these precise, cellular analyses of tissues will provide a mechanistic foundation for application of therapeutic targets and combination therapies.